Data Center: Endocrinology

Androgen regulation of gene expression in the mouse lacrimal gland

Microarray Platform:
Codelink® Uniset® Mouse I Bioarray

Reference:
Data available from GEO, dataset GSE1582.
Richards S.M., Liu M., Jensen R.V., Schirra F., Yamagami H., Lombardi M.J., Rowley P.,Treister N.S., Suzuki T., Sullivan B.D., Sullivan D.A. Androgen regulation of gene expression in the mouse lacrimal gland. J Steroid Biochem Mol Biol. 2005 Sep;96(5):401-13.

Analysis:
The authors used microarray analysis (CodeLink mouse 10K array) to examine gene expression in the lacrimal gland of orchiectomized mice that had been treated with testosterone or vehicle for 2 weeks. Data analysis performed using GeneSifter demonstrates that testosterone regulates the expression of over 2000 genes in the lacrimal gland.

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