Data Center: Cancer

Androgen control of gene expression in the mouse meibomian gland

Microarray Platform: Codelink® Uniset® Mouse I Bioarray

Reference:
Data available from GEO, dataset GSE1582.
Schirra F., Suzuki T., Richards S.M., Jensen R.V., Liu M., Lombardi M.J., Rowley P., Treister N.S., Sullivan D.A. Androgen control of gene expression in the mouse meibomian gland. Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3666-75.

Analysis:
The authors used microarray analysis (CodeLink mouse 10K array) to examine gene expression in the meibomian gland of orchiectomized mice that had been treated with testosterone or vehicle for 2 weeks. Data analysis performed using GeneSifter demonstrates that testosterone regulates the expression of more than 1590 genes in the mouse meibomian gland. These analyses demonstrate that testosterone regulates the expression of numerous genes in the mouse meibomian gland and that many of these genes are involved in lipid metabolic pathways.

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