Data Center: Oral Biology

Transcriptome analysis of orofacial development in mouse embryo

Microrray Platform:
Affymetrix® GeneChip® U74Av2 Murine Array

Reference:
Data available from GEO, dataset GDS739.
GEO Summary: Developmental gene expression profiling of fetal orofacial tissue from gestation day (GD) 12-14 embryos.

Abstract:
Gene expression profiles in fetal murine orofacial tissue were monitored using data from the Gene Expression Omnibus (GEO, GDS739). Of the more than 12,000 genes examined using the Affymetrix® GeneChip® U74Av2 Array, 411 genes were differentially expressed (at least 1.5 fold-change and less than a 5% false discovery rate) between gestation day 12 and 14. Partitioning around medoids (PAM) was used to partition the 411 genes into two discrete clusters. The biological process ontologies associated with the genes in each cluster were analyzed using a z-score report. This analysis showed that distinct biological themes were associated with each of the two patterns of gene expression.

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