Data Center: Neuroscience

Chronic contusion spinal cord injury in rats

Microarray Platform:
Affymetrix® GeneChip® Rat Genome U34A

Reference:
Data available from Gene Expression Omnibus (GEO), GSE2599 dataset.
Aimone J.B., Leasure J.L., Perreau V.M., Thallmair M.; The Christopher Reeve Paralysis Foundation Research Consortium. Spatial and temporal gene expression profiling of the contused rat spinal cord. Exp Neurol. 2004 Oct;189(2):204-21.

Abstract:
In this study, publicly available microarray data generated following spinal cord injury in adult rats was analyzed to identify the genes affected by this chronic injury. The data was generated by a study examining gene expression changes resulting from chronic injury using tissue samples 35 days post-injury (Aimone et al., 2004). These injured samples were compared to laminectomy-only controls. This dataset was analyzed with GeneSifter™ (VizX Labs, Seattle, WA). This microarray data analysis system was used to discover differentially regulated genes, and map them to candidate biological terms and pathways. Several clear patterns of gene expression were discovered which correlated with genes involved in lipid metabolism and inflammation.